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Trifluridine (Ophthalmic)

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Trifluridine (Ophthalmic)

US Brand Names

• Viroptic

Canadian Brand Names

• Viroptic

Another commonly used name is trifluorothymidine .


Trifluridine (trye-FLURE-i-deen) ophthalmic preparations are used to treat virus infections of the eye.

Trifluridine is available only with your doctor's prescription, in the following dosage form:


    • Ophthalmic solution (eye drops) (U.S. and Canada)

Special Considerations

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trifluridine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to trifluridine. Also tell your health care professional if you are allergic to any other substances, such as preservatives.


Studies have not been done in humans. When injected into developing chick embryos, trifluridine has been shown to cause birth defects. However, studies in rats and rabbits have not shown that trifluridine causes birth defects, although it did cause delayed bone formation in rats and rabbits and death in unborn rabbits.


It is unlikely that trifluridine, used in the eyes, is absorbed into the mother's body and passes into the breast milk. In addition, trifluridine has not been reported to cause problems in nursing babies.


Although there is no specific information comparing the use of trifluridine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.

Older adults

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of trifluridine in the elderly with use in other age groups.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine that is to be used in the eye.


The bottle is only partially full to provide proper drop control.

To use:

    • First, wash your hands. Then tilt the head back and pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close the eyes. Do not blink. Keep the eyes closed for 1 or 2 minutes to allow the medicine to come into contact with the infection.

    • If you think you did not get the drop of medicine into your eye properly, use another drop.

    • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.

Do not use this medicine more often or for a longer time than your doctor ordered . To do so may cause problems in the eyes. If you have any questions about this, check with your doctor.

To help clear up your infection completely, keep using this medicine for the full time of treatment , even if your symptoms have disappeared. Do not miss any doses .


The dose of ophthalmic trifluridine will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of ophthalmic trifluridine. If your dose is different, do not change it unless your doctor tells you to do so .

The number of doses you use each day, the time allowed between doses, and the length of time you use the medicine depend on the medical problem for which you are using ophthalmic trifluridine .

    • For ophthalmic solution dosage forms:

      o For viral eye infection:

        Adults and children 6 years of age and older-One drop every two hours while you are awake. After healing has occurred, the dose may be reduced for seven more days to one drop every four hours (at least 5 doses a day) while you are awake.

        Children up to 6 years of age-Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.


To store this medicine:

    • Keep out of the reach of children.

    • Store in the refrigerator because heat will cause this medicine to break down. However, keep the medicine from freezing. Follow the directions on the label.

    • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.


It is very important that you keep your appointment with your doctor. If your symptoms become worse, check with your doctor sooner.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:


Blurred vision or other change in vision; dryness of eye; irritation of eye; itching, redness, swelling, or other sign of irritation not present before use of this medicine.

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if either of the following side effects continues or is bothersome:

More common

Burning or stinging.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

March 29, 2000

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