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Travoprost (Ophthalmic)

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Travoprost (Ophthalmic)

US Brand Names

• Travatan


Travoprost is used (Trav-OH-prohst) to treat certain kind of glaucoma. It is also used to treat a condition called hypertension of the eye. Travoprost appears to work by increasing the outflow of fluid from the eye. This lowers the pressure in the eye.

This medicine is available only with your doctor's prescription, in the following dosage form:


    • Ophthalmic solution (eye drops) (U.S.)

Special Considerations

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For travoprost, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to travoprost or prostaglandins. Also tell your health care professional if you are allergic to any other substances, such as preservatives or benzalkonium chloride.


Travoprost has not been studied in pregnant women. However, in animals given very high doses, it caused some harmful effects on animals' offspring. Before using this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.


It is not known whether travoprost passes into human breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.


Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of travoprost in children with use in other age groups.

Older adults

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of travoprost in the elderly with use in other age groups.

Other medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems

The presence of other medical problems may affect the use of travoprost. Make sure you tell your doctor if you have any other medical problems, especially:

    • Eye disease, such as iritis or uveitis-Some eye conditions may be worsened by travoprost

    • Eye problems, such as loss of the lens of the eye-May be more prone to an adverse reaction called macular edema

    • Kidney disease or

    • Liver disease-Use travoprost with caution


Use this medicine only as directed . Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of too much medicine being absorbed into the body and the chance of side effects.

If your doctor ordered two different eye drops to be used together, wait at least 5 minutes between the times you apply the medicines. This will help to keep the second medicine from "washing out" the first one.

It is important that your doctor check your eye pressure at regular visits to make certain that your glaucoma is being controlled.

The preservative used in these eye drops may be absorbed by soft contact lenses and cause irritation of your eyes. Soft contact lenses should be taken out before you use travoprost eye drops. Lenses may be put back in the eyes 15 minutes after you have used the medicine.

To use:

    • The bottle is only partially full to provide proper drop control.

    • First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed for 1 to 2 minutes to allow the medicine to be absorbed by the eye.

    • Remove any excess solution around the eye with a clean tissue, being careful not to touch the eye.

    • Immediately after using the eye drops, wash your hands to remove any medicine that may be on them.

To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye) . Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye drops.


The dose of travoprost will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of travoprost. If your dose is different, do not change it unless your doctor tells you to do so.

    • For ophthalmic (eye drops) dosage form:

      o For glaucoma or hypertension of the eye:

        Adults-Use 1 drop in the affected eye(s) once a day in the evening.

        Children-Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


To store this medicine:

    • Keep out of the reach of children.

    • Store away from heat and direct light.

    • Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.


It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly and is not causing unwanted effects.

If itching, redness, swelling, or other signs of eye or eyelid irritation occur, check with your doctor. These signs may mean that you are allergic to travoprost.

Check with your doctor if you get an injury or infection in your eye or if you are scheduled to have eye surgery. Your doctor may want you to use a fresh bottle of travoprost eye drops in case the present bottle of eye drops has become contaminated during use.

This medicine may cause some people to have blurred vision for a short time after each use. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you cannot see properly.

While you are using travoprost, the iris (colored part) of your treated eye(s) may slowly become more brown in color . The change in color of the iris is noticeable usually within several months or years from the start of treatment with travoprost. In addition, there may be a darkening of eyelid skin color. Also, your eyelashes may become longer, thicker, and darker. These changes to the iris, eyelid, and lashes may be permanent even if you stop using travoprost. Also, these changes to the iris, eyelid, and lashes will affect only the eye being treated with travoprost. Therefore, if only one eye is being treated, only that eye may develop darker iris, eyelid, and eyelashes and other changes to the eyelashes, and you may have differently appearing eyes . Check with your doctor if you have any questions about this.

Travoprost may cause your eyes to become more sensitive to light than they are normally. Wearing sunglasses and avoiding too much exposure to bright light may help lessen the discomfort.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Acid or sour stomach (heartburn or indigestion); blindness; blood in urine; blurred or decreased vision; burning, dry or itching eyes; cough producing mucus; eye color changes; chest pain; chest tightness; confusion; dull nervousness; faintness or lightheadedness when getting up from a lying or sitting position; fast or irregular heartbeat; fever or chills; headache; high cholesterol; lightheadedness, dizziness or fainting; loss of bladder control; lower back pain; mood or mental changes; muscle pain or stiffness; pain, swelling, or redness in joints; pain or burning while urinating; pelvic pain; pounding in the ears; runny nose; sore throat; shortness of breath; redness, pain, swelling of eye, eyelid, or inner lining of eyelid; slow or irregular heartbeat (less than 50 beats per minute); sudden sweating; tightness in chest or wheezing; unusual tiredness.

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

More common

Decreased vision; eye discomfort; eye pain; feeling of having something in the eye; itching eye; redness of eye.

Less common

Dry eyes; eye discharge or excessive tearing; increased sensitivity of eyes to sunlight.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

July 23, 2001

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